Projects

Research Projects

Exploring neural mechanisms through computational neuroscience and advanced imaging

Project

Description

Links

Neural and behavioral organization of rapid eye movement sleep in zebrafish

2023

Discovered two distinct quiescent states in larval zebrafish sleep (qREM and qNREM), revealing the evolutionary origin of REM sleep. Used high-resolution behavioral imaging and brain-wide neural recordings.

Details Paper

Behavioral motifs identification in freely swimming zebrafish using autoregressive hidden markov models (ARHMMs)

2023

Developing and applying autoregressive hidden Markov models to identify behavioral states from high-resolution tracking data. Implemented in Julia with applications to zebrafish behavioral analysis, revealing organized behavioral motifs and state transitions.

Details GitHub

Visual-area-specific tonic modulation of GABA release by endocannabinoids in neocortex

2022

Developed end-to-end analysis pipeline for two-photon calcium imaging data (motion registration, source extraction, deconvolution, data analysis). Revealed how CB1+ interneurons differentially control neural activity and coordination in primary (V1) versus associative (V2M) visual cortex.

Details Paper

Alterations of specific cortical GABAergic circuits in Down syndrome

2020

Developed computational methods to detect Up/Down states in cortical LFP recordings. Revealed how specific GABAergic circuit alterations lead to abnormal network activity in Down syndrome mouse models.

Details Paper

Whole-Brain Imaging Pipeline

Ongoing

Developing automated pipelines for processing and analyzing large-scale whole-brain imaging data, including image registration, motion correction, and neural activity extraction.

Details GitHub

More projects and publications coming soon. Check back for updates on my latest research and collaborations.