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Vikash Choudhary

PhD Student in Biological Cybernetics
Max Planck Institute

Researching neural mechanisms underlying internal states and behavioral transitions in zebrafish through advanced imaging and computational modeling.

Vikash Choudhary

Research Focus

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Neural Mechanisms

Understanding how the brain maintains and transitions between different internal states

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Zebrafish Quiescence

Investigating neural substrates of quiescence substates using whole-brain imaging

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Computational Modeling

Applying control theory and systems biology to understand neural circuits

Research Projects

Project
Description

Neural and behavioral organization of rapid eye movement sleep in zebrafish

2023

Discovered two distinct quiescent states in larval zebrafish sleep (qREM and qNREM), revealing the evolutionary origin of REM sleep. Used high-resolution behavioral imaging and brain-wide neural recordings.

Alterations of specific cortical GABAergic circuits in Down syndrome

2020

Developed computational methods to detect Up/Down states in cortical LFP recordings. Revealed how specific GABAergic circuit alterations lead to abnormal network activity in Down syndrome mouse models.

Quiescence Substate Analysis

Ongoing

Developing novel computational methods to identify and characterize different substates of quiescence through behavioral and neural data analysis using machine learning approaches.

Whole-Brain Imaging Pipeline

Ongoing

Developing automated pipelines for processing and analyzing large-scale whole-brain imaging data, including image registration, motion correction, and neural activity extraction.

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